Background ; Coronavirus disease 2019 (COVID-19) is a rapidly emerging disease caused by a highly contagious virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), The significance of the study lies in the need to evaluate the levels of antioxidants, white blood cell (WBC) as well as platelets to lymphocyte ratio (PLR) among mild and sever COVID-19 patients so that the outcome can imply a more robust and holistic approach to combating the devastating disease. Objectives :To evaluate role of total antioxidant capacity, WBC, PLR with disease severity of COVID-19.
Patients and Methods: A purposive study was carried out in this study, which includes 60 individuals. These subjects were divided into two groups: The first group includes 30 sever COVID-19 patients and the second group includes 30mild COVID-19 patients . Blood tests were performed using routine methods for the detection of WBC, Lymphocyte, and platelets measurement . The total antioxidant capacity measurement by manual method.
Results: In this study, total antioxidant capacity, WBC, and PLR were measured in sever and mild COVID-19 patients. Results demonstrated significant alterations in total antioxidant capacity, WBC as well as PLR between two groups. Contribution of those factors with severity of the disease has been shown.
-Total Antioxidant capacity is the significant variable relates with severity of COVID-19 disease. - PLR is inflammatory marker, has been suggested to predict the severity of COVID-19 patients and may be considered as cardinal laboratory findings, with prognostic potential. WBC counts increased significantly as the disease severity increased.